Natural Drug Extracts For a Nutritive-Tonic Drink,

Natural medicine extracts for a nutritive-tonic drink, promotes the gun trigger of semipermanent potentiation in rat hippocampal dentate gyrus in vivo Yasuko Sakata, Kumiko Ishige, Tomohiro Ohtakara, Yoshihisa Ito * surgical incision of Pharmacology, College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan receive 19 December 2005; accepted 4 April 2006 Available online 11 May 2006 Abstract We have shown previously that oral brass instrument of a nutritive-tonic drink (NTD) improves scopolamine- generate store impairment in the passive turning away delegate and Morris water-maze in mice and that this action is attri saveable to the natural drug extracts, rather than synthetic substance drugs such as taurine and caffeine, in the NTD. In state to investigate the mechanism underlying the antiamnesic effectuate of the natural drug extracts, the effects of the extracts on the induction of long-term potentiation (LTP) was inves tigated in the dentate gyrus (DG) of normal and scopolaminetreated rats. Oral administration of natural drug extracts enhanced the induction of population lace amplitude generate by weak tetanic input signal (30 pulses at 60 Hz). scopolamine (0.3 mg/kg, i.p.) completely inhibited the induction of LTP bring on by both weak and infrangible tetanic stimulation (100 pulses at 100 Hz).

Natural drug extracts enhanced partly but significantly the induction of LTP by strong lockjaw, but had a very weak effect on that induced by weak tetanus. These results suggest that LTP induced by strong tetanus is sensitive to n atural drug extracts, and that the antiamne! sic effect of the NTD is at least(prenominal) partly attributable to the LTP-improving effect of the natural drug extracts in the DG. # 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. Keywords: Natural drug extracts; Long-term potentiation; hyoscine; Hippocampus; Dentate gyrus; Morris water-maze test; Nutritive-tonic drink; guardianship and memory 1. Introduction A number...If you want to get a full essay, order it on our website: OrderCustomPaper.com

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